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Nickel allergy is typically diagnosed by patch testing – applying a patch with 2.5% (in North America) or 5% (in Europe) nickel sulfate to the upper back and looking for irritation on the skin. [2] As with other causes of allergic contact dermatitis, patches containing several common allergens are typically applied to the back for 48 hours ...
Nickel is the most common contact allergen worldwide (of people with contact dermatitis, 11.4% in Europe, 8.8–25.7% in China, and 17.5% in North America are allergic to nickel). [1] Nickel allergy, and contact allergies more generally, can develop when people are any age, but they are most likely to develop in early adulthood.
Another study by the same critical author used 34 patients to test the sensitivity and specificity if the MELISA test, and concluded that it is not useful for diagnosis of contact allergy to the metals gold, palladium and nickel, since many false-positive results will be obtained (Cederbrant, et al., 1997).
Nevertheless, the term Nickel Directive is still used to refer to the restrictions on nickel usage and the prescribed test method for quantifying nickel release from products EN 1811. Allergy to nickel is a common cause of contact dermatitis, with roughly 10% of the population in Western Europe and North America being sensitive to nickel.
Coins still made with nickel alloys include one- and two-euro coins, 5¢, 10¢, 25¢, 50¢, and $1 U.S. coins, [73] and 20p, 50p, £1, and £2 UK coins. From 2012 on the nickel-alloy used for 5p and 10p UK coins was replaced with nickel-plated steel. This ignited a public controversy regarding the problems of people with nickel allergy. [68]
A patch test relies on the principle of a type IV hypersensitivity reaction.. The first step in becoming allergic is sensitization. When skin is exposed to an allergen, the antigen-presenting cells (APCs) – also known as Langerhans cell or Dermal Dendritic Cell – phagocytize the substance, break it down to smaller components and present them on their surface bound major histocompatibility ...
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