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Calcitonin. Calcitonin is a 32 amino acid peptide hormone secreted by parafollicular cells (also known as C cells) of the thyroid (or endostyle) in humans and other chordates [5] in the ultimopharyngeal body. [6] It acts to reduce blood calcium (Ca 2+), opposing the effects of parathyroid hormone (PTH). [7]
InterPro. Calcitonin gene-related peptide (CGRP) is a member of the calcitonin family of peptides consisting of calcitonin, amylin, adrenomedullin, adrenomedullin 2 (intermedin) and calcitonin‑receptor‑stimulating peptide. Calcitonin is mainly produced by thyroid C cells whilst CGRP is secreted and stored in the nervous system. [1]
Salmon calcitonin. Salmon calcitonin (sCT) [1] is the type of calcitonin hormone found in salmon. [2] Similar to humans, salmon calcitonin is a peptide hormone produced in the ultimobranchial region by parafollicular cells in response to hypercalcemia and lowers blood calcium and phosphate by promoting renal excretion.
In molecular biology, the amylin protein family or calcitonin/CGRP/IAPP protein family is a family of proteins, which includes the precursors of calcitonin / calcitonin gene-related peptide (CGRP), islet amyloid polypeptide (IAPP) and adrenomedullin. Calcitonin [1] is a 32 amino acid polypeptide hormone that causes a rapid but short-lived drop ...
Bone resorption is resorption of bone tissue, that is, the process by which osteoclasts break down the tissue in bones [1] and release the minerals, resulting in a transfer of calcium from bone tissue to the blood. [2] The osteoclasts are multi-nucleated cells that contain numerous mitochondria and lysosomes. These are the cells responsible for ...
Calcitonin receptor. The calcitonin receptor (CT) is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in maintenance of calcium homeostasis, [5] particularly with respect to bone formation and metabolism. [6][7][8]
Parafollicular cells, also called C cells, are neuroendocrine cells in the thyroid. They are called C cells because the primary function of these cells is to secrete calcitonin. [1] They are located adjacent to the thyroid follicles and reside in the connective tissue. These cells are large and have a pale stain compared with the follicular cells.
ATC code H05 Calcium homeostasis is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products. [1] [2] [3] Subgroup H05 is part of the anatomical group H Systemic hormonal ...