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The Nikolsky sign is dislodgement of intact superficial epidermis by a shearing force, indicating a plane of cleavage in the skin epidermal-epidermal junctions (e.g., desmosomes). The histological picture involves thinner, weaker attachments of the skin lesion itself to the normal skin – resulting in easier dislodgement.
SSSS is a clinical diagnosis. This is sometimes confirmed by isolation of S. aureus from blood, mucous membranes, or skin biopsy; however, these are often negative. Skin biopsy may show separation of the superficial layer of the epidermis (intraepidermal separation), differentiating SSSS from TEN, wherein the separation occurs at the dermo-epidermal junction (subepidermal separation).
[2] [3] It is seen along with Nikolsky's sign, both used to assess the severity of some blistering diseases such as pemphigus vulgaris and severe bullous drug reactions. [ 4 ] This sign is named for the Danish physician Gustav Asboe-Hansen (1917–1989), who first described it in 1960.
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The sloughing of skin associated with certain varieties of this condition is now referred to as Nikolsky's sign. In 1898, he became a professor at the Imperial University of Warsaw, and later established the Department of Dermatology and Venerology in Rostov at what is now Rostov State Medical University. [1]
After World War II, the number of single parent families in the United States increased as women began to participate in the labor force. [9] Traditional family roles and structure were tremendously altered as women began to serve as major financial contributors, increasing the average percentage of employed women from 38 percent in 1955 to 78 percent by 2004. [10]
Dougal Waters/Getty Images. Sidelines is a high-risk pregnancy support group in which volunteers lend an ear to women who are experiencing complicated pregnancies.
3-2-1 Contact is an American science educational television show produced by the Children's Television Workshop (CTW, now known as Sesame Workshop). It aired on PBS from 1980 to 1988 and later ran on Noggin (a joint venture between the CTW and Nickelodeon ) from 1999 to 2003.