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Glutathione (GSH, / ˌ ɡ l uː t ə ˈ θ aɪ oʊ n /) is an organic compound with the chemical formula HOCOCH(NH 2)CH 2 CH 2 CONHCH(CH 2 SH)CONHCH 2 COOH. It is an antioxidant in plants , animals , fungi , and some bacteria and archaea .
Chemist Warehouse Group (trading as Chemist Warehouse, My Chemist, My Beauty Spot) [3] is an Australian company operating a chain of retail pharmacies both locally and internationally. The company is one of Australia's largest pharmacy retailers with over 500 stores in Australia, [ 4 ] and employs over 20,000 staff. [ 5 ]
CoA + glutathione + NADP + CoA-glutathione + NADPH + H + The 3 substrates of this enzyme are CoA , glutathione , and NADP + , whereas its 3 products are CoA-glutathione , NADPH , and H + . This enzyme belongs to the family of oxidoreductases , specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor.
Glutathione reductase (GR) also known as glutathione-disulfide reductase (GSR) is an enzyme that in humans is encoded by the GSR gene.Glutathione reductase (EC 1.8.1.7) catalyzes the reduction of glutathione disulfide to the sulfhydryl form glutathione (), which is a critical molecule in resisting oxidative stress and maintaining the reducing environment of the cell.
Glutathione is the most common agent taken by mouth to whiten the skin. [10] It can be used as a cream. [10] It is an antioxidant normally made by the body. [10] Whether or not it actually works is unclear as of 2019. [11] Due to side effects that may result from intravenous use, the government of the Philippines recommends against such use. [12]
Glutathione synthetase deficiency has an autosomal recessive pattern of inheritance. Mutations in the GSS gene cause glutathione synthetase deficiency. This gene provides instructions for making the enzyme glutathione synthetase. This enzyme is involved in a process called the gamma-glutamyl cycle, which takes place in most of the body's cells ...
Lipoic acid (LA), also known as α-lipoic acid, alpha-lipoic acid (ALA) and thioctic acid, is an organosulfur compound derived from caprylic acid (octanoic acid). [3] ALA, which is made in animals normally, is essential for aerobic metabolism.
[11] [12] [14] Metabolites are conjugated to gluconic acid or glutathione and around 70 to 75% of 14 C-labelled trazodone was found to be excreted in the urine within 72 hours. [138] The remaining drug and its metabolites are excreted in the faeces via biliary elimination. Less than 1% of the drug is excreted in its unchanged form. [133]
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