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The Disabled-1 (Dab1) gene encodes a key regulator of Reelin signaling. Reelin is a large glycoprotein secreted by neurons of the developing brain, particularly Cajal-Retzius cells . DAB1 functions downstream of Reln in a signaling pathway that controls cell positioning in the developing brain and during adult neurogenesis .
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The spontaneous autosomal recessive scrambler mutation on chromosome 4 causes a deficiency of DAB1, encoding disabled-1, a protein involved in the signaling of the Reelin protein, lacking in the reeler mutant, [3] Dab1-scm homozygous mutants possess a reeler-like phenotype with respect to cell malpositioning in cerebellar cortex, hippocampus, and neocortex.
DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain.
In order to install AOL Tech Fortress, your system must meet the following requirements: AOL Tech Fortress is supported on Windows: Microsoft Windows 7 SP1 or later. One PC per purchase. Minimum configuration of 1GB RAM and 100 megabytes of free hard disk space, 1.80 GHz or faster 2 cores and x86/x64 compatible architectures.
While all AOL products do work best with the latest version of a browser, basic mail may still work in outdated browsers. Windows XP and newer - Works best with the latest version of Edge, Firefox, Chrome, Safari, and AOL Desktop Gold. Mac OS X and newer - Works best with the latest version of Safari, Firefox, and Chrome.
5649 19699 Ensembl ENSG00000189056 ENSMUSG00000042453 UniProt P78509 Q60841 RefSeq (mRNA) NM_173054 NM_005045 NM_011261 NM_001310464 RefSeq (protein) NP_005036 NP_774959 NP_001297393 NP_035391 Location (UCSC) Chr 7: 103.47 – 103.99 Mb Chr 5: 22.09 – 22.55 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Reelin, encoded by the RELN gene, is a large secreted extracellular matrix ...
9. Kansas. When it comes to expensive states for homeowners, the state of Kansas doesn’t often come to mind. But it has an average property tax rate of 1.26%.