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2. Insulin-like growth factor 1 - Wikipedia

   en.wikipedia.org/wiki/Insulin-like_growth_factor_1

   IGF-1 is a protein that in humans is encoded by the IGF1 gene. [8] [9] IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7,649 daltons. [10] In dogs, an ancient mutation in IGF1 is the primary cause of the toy phenotype. [11] IGF-1 is produced primarily by the liver.

3. Insulin-like growth factor - Wikipedia

   en.wikipedia.org/wiki/Insulin-like_growth_factor

   The IGF-1 receptor is the "physiological" receptor. IGF-1 binds to it at significantly higher affinity than it binds the insulin receptor. Like the insulin receptor, the IGF-1 receptor is a receptor tyrosine kinase—meaning the receptor signals by causing the addition of a phosphate molecule on particular tyrosines. The IGF-2 receptor only ...

4. Somatopause - Wikipedia

   en.wikipedia.org/wiki/Somatopause

   Somatopause is the progressive decline in the levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), hormones of the hypothalamic–pituitary–somatotropic axis (HPS axis), with age. [1] Secretion of GH may only be 60% of that of a young adult by age 70 years. [2]

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   www.aol.com/heres-know-medicares-2-000-174637852...

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6. Insulin-like growth factor-binding protein - Wikipedia

   en.wikipedia.org/wiki/Insulin-like_growth_factor...

   Approximately 98% of IGF-1 is always bound to one of six binding proteins (IGF-BP). IGFBP-3, the most abundant protein, accounts for 80% of all IGF binding. IGF-1 binds to IGFBP-3 in a 1:1 molar ratio. IGF-BP also binds to IGF-1 inside the liver, allowing growth hormone to continuously act upon the liver to produce more IGF-1.

7. Insulin-like growth factor 1 receptor - Wikipedia

   en.wikipedia.org/wiki/Insulin-like_growth_factor...

   The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1 ...