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Clopidogrel, sold under the brand name Plavix among others, is an antiplatelet medication used to reduce the risk of heart disease and stroke in those at high risk. [10] It is also used together with aspirin in heart attacks and following the placement of a coronary artery stent ( dual antiplatelet therapy ). [ 10 ]
They have a rapid onset and offset of action. This means it is often possible to pause them 12 to 48 hours before surgery and resume them shortly after the surgery. By contrast, warfarin and phenprocoumon are often paused up to a week before surgery, and low-molecular-weight heparins are used to "bridge" the therapy gap, typically for several ...
"Platelet inhibition can be demonstrated two hours after a single dose of oral clopidogrel, but the onset of action is slow, so that a loading-dose of 300–600mg is usually administered" needs clarification - if there is detectable action after 2h this is not particularly slow in most circumstances.
Metabolism of ticlopidine, clopidogrel and prasugrel to an active metabolite. Clopidogrel is a prodrug that is metabolized by two pathways. In one of the pathway most of the dose of clopidogrel (85%) is hydrolyzed by esterases to an inactive carboxylic acid derivate and rapidly cleared via glucoridination followed by renal excretion.
According to a new report by the nonprofit research organization RAND, cognitive ability, functional limitations and physical health can strongly predict the risk of developing dementia up to 20 ...
Available antiplatelet drugs have delayed onset and offset of action. [10] Since cangrelor's effects are immediate and quickly reversed, it is a more desirable drug for elective treatment of stenotic coronary arteries, high risk acute coronary syndromes treated with immediate coronary stenting, and for bridging those surgery patients who ...
Federal investigators found nearly a dozen children to be working dangerous, overnight shifts at Seaboard Triumph Foods' pork processing plant in Sioux City, Iowa, the Department of Labor ...
A San Jose State women’s volleyball player is eligible to play in her conference tournament this week, a federal judge in Denver ruled Monday, despite complaints from competitors who object to ...