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Fisher considered this small vessel disease to be the result of hypertension, induced in the acute stage by fibrinoid necrosis that would lead to occlusion and hence lacunar stroke. However, recent evidence suggests that endothelial dysfunction as a result of inflammation is a more likely cause for it.
Multi-infarct dementia results from a series of small strokes affecting several brain regions. Stroke-related dementia involving successive small strokes causes a more gradual decline in cognition. [4] Dementia may occur when neurodegenerative and cerebrovascular pathologies are mixed, as in susceptible elderly people (75 years and older).
It affects all of the vessels: very small blood vessels (capillaries), medium-size blood vessels (arterioles and venules), or large blood vessels (arteries and veins). If blood flow in a vessel with vasculitis is reduced or stopped, the parts of the body that receive blood from that vessel begins to die, resulting in a stroke .
The onset of this disease is typically between 54 – 66 years of age and the first symptoms are usually mental deterioration or stroke. [4] The vessels that supply the subcortical white matter come from the vessels that support basal ganglia, internal capsule, and thalamus. It is described as its own zone by and susceptible to injury.
The most common presentation of cerebrovascular disease is an ischemic stroke or mini-stroke and sometimes a hemorrhagic stroke. [2] Hypertension (high blood pressure) is the most important contributing risk factor for stroke and cerebrovascular diseases as it can change the structure of blood vessels and result in atherosclerosis . [ 5 ]
Many risk factors can lead to a stroke, but the magnitude of risk from some of these conditions or behaviors may have a stronger association with severe stroke compared with mild stroke, according ...
In recent years, more adults between the ages of 45 and 64 have been ... stroke death rates for middle-aged adults increased 7% between 2012 and 2019, and increased an additional 12% through 2021 ...
Approximately 17 million people had stroke in 2010 and 33 million people have previously had stroke and were still alive. [19] Between 1990 and 2010 the incidence of stroke decreased by approximately 10% in the developed world and increased by 10% in the developing world. [19] Overall, two-thirds of stroke occurred in those over 65 years old. [19]
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