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As a multi-component reaction, the Hantzsch pyridine synthesis is much more atom efficient with a simpler number of reaction steps than a linear-strategy synthesis.In recent years, research has looked to make this an even more environmentally friendly reaction by investigating "greener" solvents and reaction conditions. [15]
The first documented multicomponent reaction was the Strecker synthesis of α-amino cyanides in 1850 from which α-amino acids could be derived. ... Hantzsch pyridine ...
This was the first synthesis of a heteroaromatic compound. [24] [40] The first major synthesis of pyridine derivatives was described in 1881 by Arthur Rudolf Hantzsch. [41] The Hantzsch pyridine synthesis typically uses a 2:1:1 mixture of a β-keto acid (often acetoacetate), an aldehyde (often formaldehyde), and ammonia or
Hantzsch ester refers to an organic compound with the formula HN(MeC=C(CO 2 Et)) 2 CH 2 where Me = methyl (CH 3) and Et = ethyl (C 2 H 5). It is a light yellow solid. The compound is an example of a 1,4-dihydropyridine. It is named after Arthur Rudolf Hantzsch who described its synthesis in 1881.
Hantzsch studied chemistry in Dresden and graduated at the University of Würzburg under Johannes Wislicenus. As a professor, he taught at the Universities of Zürich, Würzburg und Leipzig. The Hantzsch pyridine synthesis, [1] a multi-component organic reaction, is named after him, as is the Hantzsch pyrrole synthesis and the Hantzsch thiazole ...
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Hantzsch ester; Hantzsch pyridine synthesis; K. Kröhnke pyridine synthesis This page was last edited on 18 June 2016, at 10:07 (UTC). Text ...