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Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. [1] It typically results in warm, swollen, and painful joints. [1] Pain and stiffness often worsen following rest. [1] Most commonly, the wrist and hands are involved, with the same joints typically involved on both sides of the body. [1]
Due to the extensive risk of side effects associated with the use of corticosteroids, it is generally recommended for short term therapy. For example, during a flare-up or an episode of arthritic symptoms, short-term corticosteroids are administered to rapidly decrease inflammation of the joints.
Upadacitinib was superior to placebo and adalimumab for improving signs, symptoms and physical function in RA participants on background methotrexate, and significantly inhibited radiographic progression versus placebo, while the overall safety profile was generally similar to adalimumab, except for higher rates of herpes zoster and CPK ...
Common side effects include infections, acute infusion reactions, and abdominal pain. [23] Infliximab is a chimeric monoclonal antibody biologic. It seems to work by binding to and neutralizing TNF-α, preventing it from interacting with its receptors on the cell. [23] TNF-α is a chemical messenger and a key part of the autoimmune reaction.
Adalimumab, sold under the brand name Humira and others, is a disease-modifying antirheumatic drug and monoclonal antibody used to treat rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, plaque psoriasis, hidradenitis suppurativa, and uveitis.
Filgotinib, sold under the brand name Jyseleca, is a medication used for the treatment of rheumatoid arthritis (RA). [3] It was developed by the Belgian-Dutch biotech company Galapagos NV. [6] The most common side effects include nausea (feeling sick), upper respiratory tract infection (nose and throat infection), urinary tract infection and ...
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