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Percutaneous umbilical cord blood sampling (PUBS), also called cordocentesis, fetal blood sampling, or umbilical vein sampling is a diagnostic genetic test that examines blood from the fetal umbilical cord to detect fetal abnormalities. [1] Fetal and maternal blood supply are typically connected in utero with one vein and two arteries to the fetus.
Fetal scalp blood testing for lactate became well-known in the 1990s. One study has shown that there is a correlation between both umbilical cord pH and lactate measurement in fetus arterial blood. [13] From a physiological standpoint, lactate levels in tissues earlier increase before pH decreases in oxygenation deficiency.
Fetoscopy is an endoscopic procedure during pregnancy to allow surgical access to the fetus, the amniotic cavity, the umbilical cord, and the fetal side of the placenta.A small (3–4 mm) incision is made in the abdomen, and an endoscope is inserted through the abdominal wall and uterus into the amniotic cavity.
Cord blood is composed of all the elements found in whole blood – red blood cells, white blood cells, plasma, platelets. [6] Compared to whole blood some differences in the blood composition exist, for example, cord blood contains higher numbers of natural killer cells, lower absolute number of T-cells and a higher proportion of immature T-cells. [7]
Another test using blood taken from the fetal umbilical cord is percutaneous umbilical cord blood sampling. Predictive and presymptomatic testing – used to detect gene mutations associated with disorders that appear after birth, often later in life.
The use of cord blood stem cells in treating conditions such as brain injury [39] and Type 1 Diabetes [40] is already being studied in humans, and earlier stage research is being conducted for treatments of stroke, [41] [42] and hearing loss. [43] Cord blood stored with private banks is typically reserved for use of the donor child only.
Gynecological cancers account for about 1 in 4 cases (primarily ovarian cancer and also uterine cancer). Nodules will also, rarely, originate from appendix cancer spillage and pseudomyxoma peritonei. Unknown primary tumors and rarely, urinary or respiratory tract malignancies can cause umbilical metastases. [4]
Anatomy scan image of a human placenta and umbilical cord (colour Doppler rendering) showing central placement of the cord in the placenta and three vessels in the cord, which is the normal physiology. A standard anatomy scan typically includes: [4] Fetal number, including number of amnionic sacs and chorionic sacs for multiple gestations
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