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Like many other medical conditions, obesity is the result of an interplay between environmental and genetic factors. [2] [3] Studies have identified variants in several genes that may contribute to weight gain and body fat distribution; although, only in a few cases are genes the primary cause of obesity.
The extreme endpoint of this distribution are the so-called 'monogenic' obesities where most of the impact on body weight can be tied to a mutation in a single gene that runs in a single family. The classic example of such a genetic effect is the presence of mutations in the leptin gene. [29]
Myostatin-related muscle hypertrophy is a rare genetic condition characterized by reduced body fat and increased skeletal muscle size. [1] Affected individuals have up to twice the usual amount of muscle mass in their bodies, but increases in muscle strength are not usually congruent. [ 2 ]
PARGC1A gene key to weight loss. At the study’s conclusion, researchers found that participants in the exercise group who had the most “skinny genes” lost up to 5 kg (about 11 lbs) during ...
“This means that if someone with small fat cells does gain weight, it may not raise their risk of conditions such as type 2 diabetes and high blood pressure as much as if they had large fat ...
Other critics suggest that race itself may affect the way obesity presents itself in individuals. In a recent study of 70,000 men and women of African ancestry, researchers found three new common genetic variants. [14] These single-nucleotide polymorphisms (SNPs) are connected to body mass index (BMI) and obesity. Therefore, individuals who ...
A lesser-known fact about weight loss is that your body’s needs and metabolism change after losing weight, according to research.To put it into context, a 110-pound person requires much fewer ...
Over 200 genes affect weight by determining activity level, food preferences, body type, and metabolism. [36] Having two copies of the allele called FTO increases the likelihood of both obesity and diabetes. [37] As such, obesity is a major feature of a number of rare genetic conditions that often present in childhood: