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Rosuvastatin has multiple contraindications, including hypersensitivity to rosuvastatin or any component of the formulation, active liver disease, elevation of serum transaminases, pregnancy, or breastfeeding. [4] Rosuvastatin is not prescribed nor used while pregnant, as it can cause serious harm to the fetus. [4]
They are prescribed typically to people who are at high risk of cardiovascular disease. [1] ... rosuvastatin, and pravastatin, are less toxic than lipophilic statins, ...
Type 2 statins have unique fluorophenyl group that causes additional polar interaction between the enzyme and the statins, which results in a tighter binding to the enzyme. The newest statin, rosuvastatin has a unique polar methane sulfonamide group, which is quite hydrophilic and confers low lipophilicity. The sulfonamide group forms a unique ...
Researchers say women with heart disease are less likely to be prescribed cholesterol-lowering medications such as statins than men with the same conditions
Ezetimibe/rosuvastatin, sold under the brand name Ridutrin among others, is a combination medication used to treat high cholesterol. [ 6 ] [ 7 ] In some countries it is sold as a kit or a pack containing two distinct pills.
Fenofibrate (sold under the brand name Tricor among others), is an oral medication of the fibrate class used to treat abnormal blood lipid levels. [3] It is less commonly used compared to statins because it treats a different type of cholesterol abnormality to statins.
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JUPITER was a randomized double-blind placebo-controlled study investigating the use of rosuvastatin in the primary prevention of cardiovascular disease.The trial focused on patients with normal low-density lipoprotein (LDL) cholesterol levels but increased levels of high-sensitivity C-reactive protein (hs-CRP).
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