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Together with Alexander Rudensky, Janeway also characterized how self antigens associate with MHC class II molecules. [6] Janeway is particularly well known as the lead author of Immunobiology, a standard textbook on immunology. Since the 2008 publishing of its seventh edition, it has been renamed as Janeway's Immunobiology in his memory. [7]
The following outline is provided as an overview of and topical guide to immunology: . Immunology – study of all aspects of the immune system in all organisms. [1] It deals with the physiological functioning of the immune system in states of both health and disease; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency ...
The 8th edition of Janeway's Immunobiology defines tolerance as "immunologically unresponsive...to another's tissues.". [ 2 ] Immune tolerance encompasses the range of physiological mechanisms by which the body reduces or eliminates an immune response to particular agents.
Scheme of the complement system. The complement system, also known as complement cascade, is a part of the humoral, innate immune system and enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and attack the pathogen's cell membrane. [1]
The clonal selection theory can be summarised with the following four tenets: Each lymphocyte bears a single type of receptor with a unique specificity (generated by V(D)J recombination).
Immunoglobulin M (IgM) is the largest of several isotypes of antibodies (also known as immunoglobulin) that are produced by vertebrates.IgM is the first antibody to appear in the response to initial exposure to an antigen; [1] [2] causing it to also be called an acute phase antibody.
Immunophysics is a novel interdisciplinary research field using immunological, biological, physical and chemical approaches to elucidate and modify immune-mediated mechanisms and to expand our knowledge on the pathomechanisms of chronic immune-mediated diseases such as arthritis, inflammatory bowel disease, asthma and chronic infections.
Priming is the first contact that antigen-specific T helper cell precursors have with an antigen.It is essential to the T helper cells' subsequent interaction with B cells to produce antibodies. [1]
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