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The cell cycle inhibitor p27kip1 has also been found to encourage regrowth of cochlear hair cells in mice following genetic deletion or knock down with siRNA targeting p27. [ 36 ] [ 37 ] Research on hair cell regeneration may bring us closer to clinical treatment for human hearing loss caused by hair cell damage or death.
The organ of Corti is located in the scala media of the cochlea of the inner ear between the vestibular duct and the tympanic duct and is composed of mechanosensory cells, known as hair cells. [2] Strategically positioned on the basilar membrane of the organ of Corti are three rows of outer hair cells (OHCs) and one row of inner hair cells ...
The CA areas are all filled with densely packed pyramidal cells similar to those found in the neocortex. After CA1 comes an area called the subiculum. After this comes a pair of ill-defined areas called the presubiculum and parasubiculum, then a transition to the cortex proper (mostly the entorhinal area of the cortex).
Three rows consist of outer hair cells (OHCs) and one row consists of inner hair cells (IHCs). The inner hair cells provide the main neural output of the cochlea. The outer hair cells, instead, mainly 'receive' neural input from the brain, which influences their motility as part of the cochlea's mechanical "pre-amplifier".
Humans have two otolithic organs on each side, one called the utricle, the other called the saccule. The utricle contains a patch of hair cells and supporting cells called a macula. Similarly, the saccule contains a patch of hair cells and a macula. Each hair cell of a macula has forty to seventy stereocilia and one true cilium called a ...
They have relatively large diameters, are bipolar, and are myelinated. Each type I axon innervates only a single inner hair cell, but each inner hair cell is innervated by up to 30 such nerve fibers, depending on species and location within the cochlea. Type II neurons make up the remaining 5-10% of the neurons and innervate the outer hair cells.
The otolith organs are beds of sensory cells in the inner ear, specifically small patches of hair cells. Overlying the hair cells and their hair bundles is a gelatinous layer and above that layer is the otolithic membrane. [1] The utricle serves to measure horizontal accelerations and the saccule responds to vertical accelerations.
Within the ampulla is a mound of hair cells and supporting cells called crista ampullaris. These hair cells have many cytoplasmic projections on the apical surface called stereocilia which are embedded in a gelatinous structure called the cupula. As the head rotates, the duct moves, but the endolymph lags behind owing to inertia. This deflects ...