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Exocytosis (/ ˌ ɛ k s oʊ s aɪ ˈ t oʊ s ɪ s / [1] [2]) is a form of active transport and bulk transport in which a cell transports molecules (e.g., neurotransmitters and proteins) out of the cell (exo-+ cytosis). As an active transport mechanism, exocytosis requires the use of energy to transport material.
Kiss-and-run fusion is a type of synaptic vesicle release where the vesicle opens and closes transiently. In this form of exocytosis, the vesicle docks and transiently fuses at the presynaptic membrane and releases its neurotransmitters across the synapse, after which the vesicle can then be reused.
Exocytosis is the process by which a large amount of molecules are released; thus it is a form of bulk transport. Exocytosis occurs via secretory portals at the cell plasma membrane called porosomes. Porosomes are permanent cup-shaped lipoprotein structures at the cell plasma membrane, where secretory vesicles transiently dock and fuse to ...
Eventually, there is vesicle fusion with the cell membrane at porosomes, by a process called exocytosis, dumping its contents out of the cell's environment. [2] Strict biochemical control is maintained over this sequence by usage of a pH gradient: the pH of the cytosol is 7.4, the ER's pH is 7.0, and the cis-golgi has a pH of 6.5.
Vesicle fusion is the merging of a vesicle with other vesicles or a part of a cell membrane.In the latter case, it is the end stage of secretion from secretory vesicles, where their contents are expelled from the cell through exocytosis.
Endocytosis and exocytosis are both forms of bulk transport that move materials into and out of cells, respectively, via vesicles. [34] In the case of endocytosis, the cellular membrane folds around the desired materials outside the cell. [35] The ingested particle becomes trapped within a pouch, known as a vesicle, inside the cytoplasm.
The vesicle exocytosis is thought to be driven by a protein complex called SNARE, that is the target for botulinum toxins. Once released, a neurotransmitter enters the synapse and encounters receptors. Neurotransmitter receptors can either be ionotropic or g protein coupled.
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