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Lansoprazole, sold under the brand name Prevacid among others, is a medication which reduces stomach acid. [4] It is a proton pump inhibitor (PPI), used to treat peptic ulcer disease, gastroesophageal reflux disease, and Zollinger–Ellison syndrome. [5] Its effectiveness is similar to that of other PPIs. [6] It is taken by mouth. [4]
Omeprazole was the first PPI on the market, in 1988. It is a 1:1 racemate drug with a backbone structure of timoprazole, but substituted with two methoxy and two methyl groups. One of the methoxy group is at position 6 of the bensoimidazole and the other at position 4 of the pyridine and the methyl groups are at position 3 and 5 of the pyridine.
The role of antibiotic in the therapies is to eradicate H. pylori, while the action of PPI is to reduce gastric acid secretion. The anti-ulcer dosing regimens generally repair the injury of gastric mucosal layer in PUD. Examples of dosing regimen: [17] Amoxicillin + clarithromycin + PPI; Bismuth subsalicylate + tetracycline + metronidazole + PPI
Proton-pump inhibitors have largely superseded the H 2-receptor antagonists, a group of medications with similar effects but a different mode of action, and heavy use of antacids. [3] A potassium-competitive acid blocker (PCAB) revaprazan was marketed in Korea as an alternative to a PPI.
These drugs are among the most widely sold drugs in the world, and are generally considered effective. [3] When these medications are used long term, the lowest effective dose should be taken. [4] They may also be taken only when symptoms occur in those with frequent problems. [5] Proton-pump inhibitors are named using the suffix "-prazole".
[3] Dexlansoprazole was approved for medical use in the United States in 2009. [3] In Canada in 2016, it was the most expensive Proton-pump inhibitor (PPI) available. [4] In 2022, it was the 186th most commonly prescribed medication in the United States, with more than 2 million prescriptions. [6] [7]
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