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A systemic disease is one that affects a number of organs and tissues, or affects the body as a whole. [1] It differs from a localized disease , which is a disease affecting only part of the body (e.g., a mouth ulcer ).
Multisystem inflammatory syndrome may refer to: . Multisystem inflammatory syndrome in children (also known as 'paediatric multisystem inflammatory syndrome', or 'paediatric inflammatory multisystem syndrome' - 'PIMS'), a rare life-threatening illness resembling Kawasaki disease that has been observed following exposure to the virus responsible for COVID-19; [1] [2] [3] while a similar ...
Early infection tends to be associated with mild or no symptoms, while the later pulmonary phase, which can be life-threatening in adults, is usually mild or absent. [32] [33] While cases of children with severe symptoms are exceptional, they can occasionally require intensive care. [34] [35] [36] Fatalities have been rare. [33] [37]
SIRS is a serious condition related to systemic inflammation, organ dysfunction, and organ failure. It is a subset of cytokine storm, in which there is abnormal regulation of various cytokines. [6] SIRS is also closely related to sepsis, in which patients satisfy criteria for SIRS and have a suspected or proven infection. [2] [3] [4] [7]
Pneumonia is an infection that causes inflammation in one or both lungs. The pulmonary alveoli fill with fluid or pus making it difficult to breathe. [1] Pneumonia can be caused by bacteria, viruses, fungi or parasites. [1] Viruses are the most common cause of pneumonia in children, while in adults bacteria are a more common cause. [2]
In one study, 81% of children with active systemic symptoms had abnormal echocardiographic findings, and 36% of patients had an effusion or pericardial thickening. The majority of pericardial effusions don't cause any symptoms; they can only be identified by echocardiography and don't show any overt cardiomegaly or usual ECG abnormalities
Periodic fever syndromes are a set of disorders characterized by recurrent episodes of systemic and organ-specific inflammation.Unlike autoimmune disorders such as systemic lupus erythematosus, in which the disease is caused by abnormalities of the adaptive immune system, people with autoinflammatory diseases do not produce autoantibodies or antigen-specific T or B cells.
The disease's symptoms can range from catastrophic neurological impairment to an asymptomatic condition brought on by impalpable pulses or bruits. [7] Non-specific features include mild anemia, myalgia, arthralgia, weight loss, malaise, night sweats, and fever. [8] Giant cell arteritis (GCA) is the most common type of systemic vasculitis in adults.