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Cetuximab, sold under the brand name Erbitux, is an epidermal growth factor receptor (EGFR) inhibitor medication used for the treatment of metastatic colorectal cancer and head and neck cancer. [2] Cetuximab is a chimeric (mouse/human) monoclonal antibody given by intravenous infusion .
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Brentuximab vedotin [6] consists of the chimeric monoclonal antibody brentuximab (cAC10, which targets the cell-membrane protein CD30) linked with maleimide attachment groups, cathepsin-cleavable linkers (valine-citrulline), and para-aminobenzylcarbamate spacers to three to five units of the antimitotic agent monomethyl auristatin E (MMAE, reflected by the 'vedotin' in the drug's name). [7]
Organized coupon exchange clubs are commonly found in regions where coupons are distributed. Often coupons are available for purchase at some online sites, [26] but since most coupons are not allowed to be sold, the fee is considered to be for the time and effort put into cutting out the coupons. Some types of coupons may be sold.
Extreme couponing is an activity that combines shopping skills with couponing in an attempt to save as much money as possible while accumulating the most groceries. The concept of "extreme couponers" was first mentioned by The Wall Street Journal on March 8, 2010, in an article entitled "Hard Times Turn Coupon Clipping Into the Newest Extreme Sport". [2]
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