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Lisaftoclax is an investigational new drug being developed by Ascentage Pharma for the treatment of hematological malignancies, particularly chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL).
55-21-0 3D model ... 1.341 g/cm 3: Melting point: 127 to 130 °C (261 to 266 °F; 400 to 403 K) ... Benzamide is an organic compound with the chemical formula of C 7 ...
U-77891 is an opioid analgesic drug that was first synthesized in 1983 by the Upjohn company. [1] It was originally synthesized to prove that the removal of a single methylene spacer of the benzamide would alter a κ-opioid receptor agonist such as U-50488 into an μ-opioid receptor agonist, as well as producing a semi-rigid derivative of U-47700.
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Alkylation of the sodium salt of p-hydroxybenzaldehyde (1) with 2-dimethylaminoethyl chloride affords the ether (2). Reductive amination of the aldehyde in the presence of ammonia gives diamine (3). Acylation of that product with 3,4,5-trimethoxybenzoyl chloride affords trimethobenzamide (4).
In North America and Europe, the annual number of new cases per year of kidney stones is roughly 0.5%. In the United States, the frequency in the population of urolithiasis has increased from 3.2% to 5.2% from the mid-1970s to the mid-1990s. [21] In the United States, about 9% of the population has had a kidney stone.
Tecovirimat, sold under the brand name Tpoxx among others, [6] is an antiviral medication with activity against orthopoxviruses such as smallpox and mpox. [4] [7] [8] In 2018 it was the first antipoxviral drug approved in the United States.
Ameltolide, a 4-aminobenzamide derivative, is an experimental anticonvulsant agent, effective at inhibiting seizures in animal models. [1] It is non-toxic at dosing levels and no undesirable side effects are attributable to its application.