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Norrie disease is a rare X-linked recessive genetic disorder that primarily affects the eyes and almost always leads to blindness.It is caused by mutations in the Norrin cystine knot growth factor gene, also referred to as Norrie Disease Pseudoglioma (NDP) gene.
Additionally, fluctuations in pressure within the thoracic cavity during apnea episodes can alter intraocular pressure, affecting the blood supply to the optic nerve head . Sleep apnea often causes dips in blood pressure during sleep, particularly in the early morning hours, reducing blood supply to the optic nerve head and increasing the risk ...
Optic neuropathy is damage to the optic nerve from any cause. The optic nerve is a bundle of millions of fibers in the retina that sends visual signals to the brain. Damage and death of these nerve cells, or neurons, leads to characteri
The outer ear, external ear, or auris externa is the external part of the ear, which consists of the auricle (also pinna) and the ear canal. [1] It gathers sound energy and focuses it on the eardrum ( tympanic membrane ).
The combination of anemia and low blood pressure means that the blood is carrying less oxygen to the tissues. The optic nerve can be at very high risk for damage from insufficient blood supply due to swelling (from lack of oxygen) in a confined bony space resulting in a compartment syndrome. Restricted blood flow can lead to permanent damage to ...
acute visual loss (sudden blindness) diplopia (double vision) limb claudication [12] polymyalgia rheumatica (in 50%) [13] The inflammation may affect blood supply to the eye; blurred vision or sudden blindness may occur. In 76% of cases involving the eye, the ophthalmic artery is involved, causing arteritic anterior ischemic optic neuropathy. [14]
Temporal arteritis is an inflammatory disease of medium-sized blood vessels that happens especially with advancing age. AAION occurs in about 15-20 percent of patients with temporal arteritis. Damage to the blood vessels supplying the optic nerves leads to insufficient blood supply ( ischemia ) to the nerve and subsequent optic nerve fiber death.
The outer ear is the external portion of the ear and includes the fleshy visible auricle, the ear canal, and the outer layer of the eardrum (also called the tympanic membrane). [2] [3] The auricle consists of the curving outer rim called the helix, the inner curved rim called the antihelix, and opens into the ear canal.
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