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The first modern epinephrine autoinjector, the EpiPen, was invented in the mid-1970s at Survival Technology in Bethesda, Maryland, US by Sheldon Kaplan [11] [12] and was first approved for marketing by the FDA in 1987. [13] One of the people who helped in making the EpiPen was Richard B. Toren.
Following a 0.3 mg oral dose, a small study of five patients by Dollery et al. (1976) found half-lives ranging between 6.3 and 23.4 hours (mean 12.7). [94] A similar N=5 study by Davies et al. (1977) found a narrower range of half-lives, between 6.7 and 13 hours (mean 8.6), [ 4 ] while an N=8 study by Keraäen et al. that included younger ...
There is an epinephrine metered-dose inhaler sold over the counter in the United States to relieve bronchial asthma. [67] [68] It was introduced in 1963 by Armstrong Pharmaceuticals. [69] A common concentration for epinephrine is 2.25% w/v epinephrine in solution, which contains 22.5 mg/mL, while a 1% solution is typically used for aerosolization.
Changes in appetite or weight are common among antidepressants but are largely drug-dependent and related to which neurotransmitters they affect. Mirtazapine and paroxetine , for example, may be associated with weight gain and/or increased appetite, [ 178 ] [ 179 ] [ 180 ] while others (such as bupropion and venlafaxine ) achieve the opposite ...
This is a list of mnemonics used in medicine and medical science, categorized and alphabetized. A mnemonic is any technique that assists the human memory with information retention or retrieval by making abstract or impersonal information more accessible and meaningful, and therefore easier to remember; many of them are acronyms or initialisms which reduce a lengthy set of terms to a single ...
Phenylpropanolamine is a small-molecule compound with the molecular formula C 9 H 13 NO and a molecular weight of 151.21 g/mol. [52] [8] It has an experimental log P of 0.67, while its predicted log P values range from 0.57 to 0.89. [52] [8] The compound is relatively lipophilic, [5] but is also more hydrophilic than other amphetamines. [6]
Experiments indicate that the median lethal dose (LD 50) on tested female rats is 0.36 mg/kg. [23] Approximately 46 proteins have been identified in the red imported fire ant's venom, [9] although scientists have long believed the venom only contained alkaloids.
Diabetes is typically diagnosed by a blood test showing unusually high blood sugar. The World Health Organization defines diabetes as blood sugar levels at or above 7.0 mmol/L (126 mg/dL) after fasting for at least eight hours, or a glucose level at or above 11.1 mmol/L (200 mg/dL) two hours after an oral glucose tolerance test. [45]
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