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Uterotonic properties, [5] nausea vomiting, and diarrhea, [12] contraindicated for pregnancy and breast feeding [12] Buckthorn bark and berry alder buckthorn Rhamnus frangula "abdominal pain, diarrhea, potentially carcinogenic, with others can potentiate cardiac glycosides and antiarrhythmic agents" [3] Cascara sagrada bark bearberry Rhamnus ...
Just last August, Sage Therapeutics got FDA approval for its pill form of this drug, zuranolone (Zurzuvae), which has shown to ease symptoms of postpartum depression in as little as three days.
Side effects of brexanolone may include sedation, sleepiness, dry mouth, hot flashes, and loss of consciousness. [ 6 ] [ 11 ] It is a neurosteroid and acts as a positive allosteric modulator of the GABA A receptor , the major biological target of the inhibitory neurotransmitter γ-aminobutyric acid (GABA).
Zuranolone, sold under the brand name Zurzuvae, is a medication used for the treatment of postpartum depression. [5] [6] It is taken by mouth.[5]The most common side effects include drowsiness, dizziness, diarrhea, fatigue, nasopharyngitis, and urinary tract infection.
Side effects associated with etifoxine use include slight drowsiness, headache, skin eruptions, and allergic reactions. [2] [8] [9] In rare cases, etifoxine has been linked to severe skin and liver toxicity, as well as menstrual bleeding between periods. [8] [1] Unlike benzodiazepines, etifoxine does not cause sedation or lack of coordination.
The research into the safety of benzodiazepines during pregnancy is limited and it is recommended that use of benzodiazepines during pregnancy should be based on whether the benefits outweigh the risks. If chlordiazepoxide is used during pregnancy the risks can be reduced via using the lowest effective dose and for the shortest time possible.
[17] [4] It also has functional antiandrogenic effects by decreasing the circulating free fractions of androgens. [18] CPA is a progestin (synthetic progestogen ), or an agonist of the progesterone receptors , the biological target of progestogens like progesterone .
An article from 2013 described the effects from overdose (in a 19-year-old female) as including vomiting, seizures and fatal cardiac toxicity. [ 18 ] In 2016, the young Russian chess player Ivan Bukavshin died of a massive overdose (or poisoning) of the drug, which was initially thought to be a stroke; the dose detected in his blood was 17 mg/kg.