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2. Heart failure with preserved ejection fraction - Wikipedia

   en.wikipedia.org/wiki/Heart_failure_with...

   Heart failure with preserved ejection fraction (HFpEF) is a form of heart failure in which the ejection fraction – the percentage of the volume of blood ejected from the left ventricle with each heartbeat divided by the volume of blood when the left ventricle is maximally filled – is normal, defined as greater than 50%; [1] this may be measured by echocardiography or cardiac catheterization.

3. Coronary artery disease - Wikipedia

   en.wikipedia.org/wiki/Coronary_artery_disease

   Coronary artery disease (CAD), also called coronary heart disease (CHD), or ischemic heart disease (IHD), [13] is a type of heart disease involving the reduction of blood flow to the cardiac muscle due to a build-up of atheromatous plaque in the arteries of the heart. [5] [6] [14] It is the most common of the cardiovascular diseases. [15]

4. Cardiology - Wikipedia

   en.wikipedia.org/wiki/Cardiology

   Heart failure, or formally cardiomyopathy, is the impaired function of the heart, and there are numerous causes and forms of heart failure. The causes of cardiomyopathy can be genetic, viral, or lifestyle-related. Key symptoms of cardiomyopathy include shortness of breath, fatigue, and irregular heartbeats.

5. Fatigue - Wikipedia

   en.wikipedia.org/wiki/Fatigue

   Fatigue is a state of tiredness (which is not sleepiness), exhaustion [1] or loss of energy. [2] [3]Fatigue (in the medical sense) is sometimes associated with medical conditions including autoimmune disease, organ failure, chronic pain conditions, mood disorders, heart disease, infectious diseases, and post-infectious-disease states. [4]

6. Spironolactone - Wikipedia

   en.wikipedia.org/wiki/Spironolactone

   Spironolactone improves left ventricular diastolic function in patients with heart failure with preserved ejection fraction, however it has no effect on mortality and hospitalization. [ 43 ] [ 44 ] Due to its antiandrogenic properties, spironolactone can cause effects associated with low androgen levels and hypogonadism in males.

7. Obstructive sleep apnea - Wikipedia

   en.wikipedia.org/wiki/Obstructive_sleep_apnea

   In severe and prolonged cases, increased in pulmonary pressures are transmitted to the right side of the heart. This can result in a severe form of congestive heart failure known as cor pulmonale. Diastolic function of the heart also becomes affected. [160] Elevated arterial pressure (i.e., hypertension) can be a consequence of OSA syndrome. [161]