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  2. Pomalidomide - Wikipedia

    en.wikipedia.org/wiki/Pomalidomide

    Pomalidomide, sold under the brand names Pomalyst and Imnovid, [7] [8] is an anti-cancer medication used for the treatment of multiple myeloma and AIDS-related Kaposi sarcoma. [ 7 ] Pomalidomide was approved for medical use in the United States in February 2013, [ 10 ] and in the European Union in August 2013. [ 8 ]

  3. Cereblon E3 ligase modulator - Wikipedia

    en.wikipedia.org/wiki/Cereblon_E3_ligase_modulator

    The thalidomide molecule is a synthetic derivative of glutamic acid and consists of a glutarimide ring and a phthaloyl ring (Figure 5). [15] [16] Its IUPAC name is 2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione and it has one chiral center [15] After thalidomide's selective inhibition of TNF-α had been reported, a renewed effort was put in thalidomide's clinical development.

  4. Lenalidomide - Wikipedia

    en.wikipedia.org/wiki/Lenalidomide

    Lenalidomide is used to treat multiple myeloma. [11] It is a more potent molecular analog of thalidomide, which inhibits tumor angiogenesis, tumor-secreted cytokines, and tumor proliferation through induction of apoptosis.

  5. 30 moves for 30 teams: One player every MLB club should sign ...

    www.aol.com/30-moves-30-teams-one-112017122.html

    Winning NL Rookie of the Year means he gets a full year of service time, and five more before he might test the waters. Well, Year 2 looks like a similarly disjointed roster, unless you’re a fan ...

  6. The best laundry detergent sheets of 2025 - AOL

    www.aol.com/lifestyle/best-laundry-detergent...

    Unless you’re trying out multiple laundry detergent sheet brands, you probably won’t notice this, but Sheets Laundry Club comes in a sturdy box that slides out of a sleeve.

  7. Is It Safe to Take Cialis Daily? - AOL

    www.aol.com/lifestyle/safe-cialis-daily...

    Risks of Daily Cialis. Using Cialis on a daily basis is mostly positive, but it does have a few potential disadvantages, including the risk of mild side effects lasting for longer and the ...

  8. File:Pomalidomide enantiomers.svg - Wikipedia

    en.wikipedia.org/wiki/File:Pomalidomide...

    English: Skeletal formulae of two enantiomers of pomalidomide (brand names Pomalyst and Imnovid) — (R)-(+)- and (S)-(−)-pomalidomide. This medication is used in the third-line treatment of multiple myeloma. Created with ChemDoodle 7.0.2 and Adobe Illustrator CC 2015.

  9. Searchers don’t expect to find Pennsylvania woman alive in ...

    www.aol.com/searchers-don-t-expect-pennsylvania...

    The search for a woman who is believed to have fallen into a sinkhole in western Pennsylvania has become a recovery effort after two treacherous days of digging through mud and rock produced no ...