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The database also contains MHC binding data from a variety of different antigenic sources and immune epitope data from the FIMM (Brusic), HLA Ligand (Hildebrand), TopBank (Sette), and MHC binding (Buus) databases. These databases and their investigators are hereby acknowledged as major contributors to the IEDB.
The Immune Epitope Database (IEDB, www.iedb.org), provides a catalog of experimentally characterized B and T cell epitopes, as well as data on MHC binding and MHC ligand elution experiments. The database represents the molecular structures recognized by adaptive immune receptors and the experimental contexts in which these molecules were ...
In immunology, epitope mapping is the process of experimentally identifying the binding site, or epitope, of an antibody on its target antigen (usually, on a protein). [ 1 ] [ 2 ] [ 3 ] Identification and characterization of antibody binding sites aid in the discovery and development of new therapeutics , vaccines , and diagnostics .
MHC class I and II epitopes can be reliably predicted by computational means alone, [14] although not all in-silico T cell epitope prediction algorithms are equivalent in their accuracy. [15] There are two main methods of predicting peptide-MHC binding: data-driven and structure-based. [11]
MHC tetramers are used to identify and label specific T-cells by epitope specific binding, allowing the antigen specific immune response to be analyzed in both animal model and in human. [9] MHC tetramers were originally developed using MHC class I molecules for the recognition of cytotoxic T cells , [ 10 ] [ 11 ] but over the last decade they ...
An MHC tetramer binding to T-cell receptors (left), and an MHC molecule on the surface of an antigen presenting cell binding to T-cell receptors (right) MHC tetramer molecules developed in a lab can mimic the antigen presenting complex on cells and bind to T-cells that recognize the antigen. Class I MHC molecules are made up of a polymorphic ...
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The isolation and mass spectrometric identification of MHC (major histocompatibility complex) binding peptides; Purification and identification of protein antigens binding specific antibodies (or other affinity reagents) Comparative immunoproteomics to identify proteins and pathways modulated by a specific infectious organism, disease or toxin.