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It is an autoimmune disease and a form of vasculitis that affects small- and medium-size vessels in many organs but most commonly affects the upper respiratory tract, lungs and kidneys. [6] The signs and symptoms of GPA are highly varied and reflect which organs are supplied by the affected blood vessels.
The definite diagnosis of vasculitis is established after a biopsy of involved organ or tissue, such as skin, sinuses, lung, nerve, brain, and kidney. The biopsy elucidates the pattern of blood vessel inflammation. Some types of vasculitis display leukocytoclasis, which is vascular damage caused by nuclear debris from infiltrating neutrophils. [37]
Giant cell arteritis (GCA), also called temporal arteritis, is an inflammatory autoimmune disease of large blood vessels. [4] [7] Symptoms may include headache, pain over the temples, flu-like symptoms, double vision, and difficulty opening the mouth. [3]
Vasculitis is an autoimmune disorder caused by inflammation to blood vessels. Researchers are still studying the underlying cause of vasculitis, but certain infections and toxins might play a role.
Its distinct histology reveals a pauci-immune vasculitis, or necrotizing small vessel vasculitis, with minimal or no immune deposits. [14] The most typical features of microscopic polyangiitis are renal manifestations and general symptoms; lung involvement is also frequently observed.
About one-third of people with RP might be associated with other autoimmune diseases, vasculitides and hematologic disorders. [4] Systemic vasculitis is the most common association with RP, followed by rheumatoid arthritis and systemic lupus erythematosus. [5] The following table displays the main diseases in association with RP.
Vasculitis is defined by the Mayo Clinic as inflammation of the blood vessels that can lead to organ and tissue damage. Some patients experience more long-lasting symptoms, but the condition can ...
The signs and symptoms of microscopic polyangiitis may resemble those of granulomatosis with polyangiitis (GPA) (another form of small-vessel vasculitis) but typically lacks the significant upper respiratory tract involvement (e.g., sinusitis) frequently seen in people affected by GPA. [citation needed]
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