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Clozapine, sold under the brand name Clozaril among others, is a psychiatric medication and was the first atypical antipsychotic to be discovered. [6] It is primarily used to treat people with schizophrenia and schizoaffective disorder who have had an inadequate response to two other antipsychotics, or who have been unable to tolerate other drugs due to extrapyramidal side effects.
Typical antipsychotics have equal drop-out and symptom relapse rates to atypicals when used at low to moderate dosages. [ 93 ] Clozapine is an effective treatment for those who respond poorly to other drugs ("treatment-resistant" or "refractory" schizophrenia), [ 94 ] but it has the potentially serious side effect of agranulocytosis (lowered ...
Celexa – an antidepressant of the SSRI class; Centrax – an anti-anxiety agent; Clozaril – atypical antipsychotic used to treat resistant schizophrenia; Concerta (methylphenidate) – an extended release form of methylphenidate
Both have equal drop-out and symptom relapse rates when typicals are used at low to moderate dosages. [17] There is a good response in 40–50% of patients, a partial response in 30–40%, and treatment resistance (failure of symptoms to respond satisfactorily after six weeks to two of three different antipsychotics) in the remaining 20%. [18]
N-Desmethylclozapine (NDMC), or norclozapine, is a major active metabolite of the atypical antipsychotic drug clozapine. [1] [2]Unlike clozapine, it possesses intrinsic activity at the D 2 /D 3 receptors, and acts as a weak partial agonist at these sites similarly to aripiprazole and bifeprunox. [3]
Elisabeth Finch, a former writer and co-producer for "Grey's Anatomy," faked a cancer diagnosis for years before admitting to the newsletter the Ankler last year that she never had cancer. “I ...
Before 2025, when your out-of-pocket expenses for drugs hit a certain amount, you entered the donut hole. As of this year, however, Medicare replaced the donut hole with a cap of $2,000 on your ...
Clotiapine (Entumine) is an atypical antipsychotic [2] of the dibenzothiazepine chemical class. [3] It was first introduced in a few European countries (namely, Belgium, Italy, Spain and Switzerland), Argentina, Taiwan and Israel in 1970.