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This enzyme's main function is to synthesize or degrade allosteric regulator Fru-2,6-P 2 in response to glycolytic needs of the cell or organism, as depicted in the accompanying diagram. PFK-2 and FBPase-2 Reaction. In enzymology, a 6-phosphofructo-2-kinase (EC 2.7.1.105) is an enzyme that catalyzes the chemical reaction:
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To see if the reduction of cellular F2,6BP levels was a result of direct PFKFB3 inhibition, both compounds were tried in the enzymatic cell-free assay. The study revealed that AZ67 inhibited the enzymatic activity of PFKFB3 with an IC50 of 0.018 μM, a value that is in accordance with previously published results.
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Jim Carrey isn't swearing off acting for good.. The actor returns to the big screen in the new sequel Sonic the Hedgehog 3 after previously saying in 2022 that he was "being fairly serious" about ...
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