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Radiation enteropathy is a syndrome that may develop following abdominal or pelvic radiation therapy for cancer. [ 1 ] [ 2 ] Many affected people are cancer survivors who had treatment for cervical cancer or prostate cancer .
Also a 2008 study published in Cancer Research has shown the addition of vitamin D 3 (along with calcium) to the diet of some mice fed a regimen similar in nutritional content to a new Western diet with 1000 IU cholecalciferol per day prevented colon cancer development. [33]
The signs and symptoms of colorectal cancer depend on the location of the tumor in the bowel, and whether it has spread elsewhere in the body ().The classic warning signs include: worsening constipation, blood in the stool, decrease in stool caliber (thickness), loss of appetite, loss of weight, and nausea or vomiting in someone over 50 years old. [15]
Vitamin D 3 (cholecalciferol) is produced industrially by exposing 7-dehydrocholesterol to UVB and UVC light, followed by purification. The 7-dehydrocholesterol is sourced as an extraction from lanolin, a waxy skin secretion in sheep's wool. [199] Vitamin D 2 (ergocalciferol) is produced in a similar way using ergosterol from yeast as a ...
Vitamin D compounds, specifically cholecalciferol (D3) and ergocalciferol (D2), are used in rodenticides due to their ability to induce hypercalcemia, a condition characterized by elevated calcium levels in the blood. This overdose leads to organ failure and is pharmacologically similar to vitamin D's toxic effects in humans.
The increased risk is believed to be due to the random chance of developing any cancer, the likelihood of surviving the first cancer, the same risk factors that produced the first cancer, unwanted side effects of treating the first cancer (particularly radiation therapy), and better compliance with screening. [204]
Many recent, large, well-conducted studies have shown no benefits in reducing fracture risk, cardiovascular disease, cancer prevention, or death from vitamin D supplementation,” Cutler said.
In esophageal cancer, Chen and colleagues found that vitamin D, a known suppressor of GPX1 expression via the NF-κB signaling pathway, could help to decrease the proliferative, migratory, and invasive capabilities of esophageal cancer cells. Unlike in colorectal cancer, GPX1 expression in esophageal cancer cells is thought to drive aggressive ...