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Pain wind-up is the increase in pain intensity over time when a given stimulus is delivered repeatedly above a critical rate. It is caused by repeated stimulation of group C peripheral nerve fibers, leading to progressively increasing electrical response in the corresponding spinal cord (posterior horn) neurons due to priming of the NMDA receptor based response.
Summation, which includes both spatial summation and temporal summation, is the process that determines whether or not an action potential will be generated by the combined effects of excitatory and inhibitory signals, both from multiple simultaneous inputs (spatial summation), and from repeated inputs (temporal summation).
In neurophysiology, the Compound action potential (or CAP) refers to various evoked potentials representing the summation of synchronized individual action potentials generated by a group of neurons or muscle fibers in response to a stimulus. [1]
' pain receptor ') is a sensory neuron that responds to damaging or potentially damaging stimuli by sending "possible threat" signals [1] [2] [3] to the spinal cord and the brain. The brain creates the sensation of pain to direct attention to the body part, so the threat can be mitigated; this process is called nociception .
Summation is the adding together of these impulses at the axon hillock. If the neuron only gets excitatory impulses, it will generate an action potential. If the neuron only gets excitatory impulses, it will generate an action potential.
Steff DiPardo's mysterious back pain turned out to be ankylosing spondylitis, an inflammatory disorder that causes the bones in the spine to fuse over time. ... and an estimated 1.7 million adults ...
Central sensitization of the dorsal horn neurons that is evoked from C fiber activity is responsible for temporal summation of "second pain" (TSSP). [15] This event is called 'windup' and relies on a frequency greater or equal to 0.33 Hz of the stimulus. [15] Windup is associated with chronic pain and central sensitization. [15]
The compound muscle action potential (CMAP) or compound motor action potential is an electrodiagnostic medicine investigation (electrical study of muscle function). The CMAP idealizes the summation of a group of almost simultaneous action potentials from several muscle fibers in the same area.