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PEG 400 is strongly hydrophilic. The partition coefficient of PEG 400 between hexane and water is 0.000015 (log P = − 4.8 {\displaystyle P=-4.8} ), indicating that when PEG 400 is mixed with water and hexane, there are only 15 parts of PEG400 in the hexane layer per 1 million parts of PEG 400 in the water layer.
PEG has been used as the hydrophilic block of amphiphilic block copolymers used to create some polymersomes. [18] PEG is a component of the propellent used in UGM-133M Trident II Missiles, in service with the United States Navy. [19] PEG has been used as a solvent for aryl thioether synthesis. [20]
The attachment of an inert and hydrophilic polymer was first reported around 1970 to extend blood life and control immunogenicity of proteins. [12] Polyethylene glycol was chosen as the polymer. [13] [14] In 1981 Davis and Abuchowski founded Enzon, Inc., which brought three PEGylated drugs to market. Abuchowski later founded and is CEO of ...
The PEG coating consists of hydrophilic molecules that are repulsive to protein adsorption. [11] Proteins consist of hydrophobic molecules and charge sites that want to bind to other hydrophobic molecules and oppositely charged sites. [12] By applying a thin monolayer coating of PEG, protein adsorption is prevented at the device site.
Poloxamer 407 is a hydrophilic non-ionic surfactant of the more general class of copolymers known as poloxamers.Poloxamer 407 is a triblock copolymer consisting of a central hydrophobic block of polypropylene glycol flanked by two hydrophilic blocks of polyethylene glycol (PEG).
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Macrogol 4000, pharmaceutical quality. Macrogol 3350, often in combination with electrolytes, is used for short-term relief of constipation as well as for long-term use in constipation of various causes, including in multiple sclerosis and Parkinson's disease patients (an often-overlooked non-motor symptom) as well as constipation caused by pharmaceutical drugs such as opioids and ...