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David Andrew Sinclair AO (born June 26, 1969) is an Australian-American biologist and academic known for his research on aging and epigenetics. Sinclair is a professor of genetics at Harvard Medical School and the founding director of the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging at Harvard.
Sirtris Pharmaceuticals, Inc. was a biotechnology company based in Cambridge, MA that developed therapies for type 2 diabetes, cancer, and other diseases. Conceived in 2004 by Harvard University biologist David Sinclair and Andrew Perlman, [1] and founded that year by Sinclair and Perlman, along with Christoph Westphal, Richard Aldrich, Richard Pops, and Paul Schimmel, [2] the company was ...
STACs have been discovered by Konrad Howitz of Biomol Inc and biologist David Sinclair. In September 2003, Howitz and Sinclair et al. published a highly cited paper reporting that polyphenols such as resveratrol [ 2 ] activate human SIRT1 and extend the lifespan of budding yeast (Howitz et al., Nature, 2003).
[53] [57] [58] [59] In 2004, Harvard University professor David Sinclair co-founded Sirtris Pharmaceuticals, the initial product of which was a resveratrol formulation. [60] [61] [62] Sirtris was purchased and made a subsidiary of GlaxoSmithKline in 2008 for $720 million and shut down in 2013, without successful drug development. [63] [64]
In 1991 his lab started to study genes involved in aging. [5] In 1993, Cynthia Kenyon 's lab at UCSF discovered that a single-gene mutation in ( Daf-2 ) could double the lifespan of C. elegans . That same year, David Sinclair joined the Guarente lab, and they developed the hypothesis that caloric restriction slows aging by activation of ...
The Commanders have taken a huge leap in just one offseason, thanks in large part to figuring out their quarterback. The Giants will start looking for their next quarterback soon.
In 2001, an 18-year-old committed to a Texas boot camp operated by one of Slattery’s previous companies, Correctional Services Corp., came down with pneumonia and pleaded to see a doctor as he struggled to breathe.
Aging is a bimonthly peer-reviewed open access bio-medical journal covering research on all aspects of gerontology.The journal was established in 2009 and is published by Impact Journals.