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Patients donated tissue samples, which researchers subsequently used in a plan to generate profit. GlaxoSmithKline human experiments Various 2004–2012 In 2004 GlaxoSmithKline (GSK) sponsored at least four medical trials using Hispanic and black children at New York's Incarnation Children's Center. Normally trials on children require parental ...
Some case reports also contain a literature review of other reported cases. Case reports are professional narratives that provide feedback on clinical practice guidelines and offer a framework for early signals of effectiveness, adverse events, and cost. They can be shared for medical, scientific, or educational purposes.
The San Antonio Contraceptive Study was a clinical research study published in 1971 about the side effects of oral contraceptives. Women coming to a clinic in San Antonio, Texas to prevent pregnancies were not told they were participating in a research study or receiving placebos. Ten of the women became pregnant while on placebos. [183] [184 ...
Case report forms contain data obtained during the patient's participation in the clinical trial. Before being sent to the sponsor, this data is usually de-identified (not traceable to the patient) by removing the patient's name, medical record number, etc., and giving the patient a unique study number.
[148] [149] Potti's misconduct resulted in the suspension of three clinical trials based on his research and a lawsuit filed against Duke by patients enrolled in those studies. [150] As of 2021 Potti has had 11 of their research publications retracted, and one other paper has received an expression of concern.
He presented evidence that such unethical studies were widespread and represented a systemic problem in medical research rather than exceptions. [ 73 ] [ 74 ] Beecher had been writing about human experimentation and publicizing cases that he considered to be bad practice for nearly a decade.
Case series have a descriptive study design; unlike studies that employ an analytic design (e.g. cohort studies, case-control studies or randomized controlled trials), case series do not, in themselves, involve hypothesis testing to look for evidence of cause and effect (though case-only analyses are sometimes performed in genetic epidemiology ...
Exclusion criteria concern properties of the study sample, defining reasons for which patients from the target population are to be excluded from the current study sample. Typical exclusion criteria are defined for either ethical reasons (e.g., children, pregnant women, patients with psychological illnesses, patients who are not able or willing ...