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Doxycycline, doxycycline monohydrate and doxycycline hyclate are yellow, crystalline powders with a bitter taste. The latter smells faintly of ethanol , a 1% aqueous solution has a pH of 2–3, and the specific rotation is [ α ] D 25 {\displaystyle [\alpha ]_{D}^{25}} −110° cm 3 /dm·g in 0.01 N methanolic hydrochloric acid .
Diverticulitis, also called colonic diverticulitis, is a gastrointestinal disease characterized by inflammation of abnormal pouches ...
Doxycycline is also used as a prophylactic treatment for infection by Bacillus anthracis and is effective against Yersinia pestis, the infectious agent of bubonic plague. It is also used for malaria treatment and prophylaxis, as well as treating elephantitis filariasis . [ 10 ]
Diverticulitis is defined as diverticular disease with signs and symptoms of diverticular inflammation. Clinical features of acute diverticulitis include constant abdominal pain, localized abdominal tenderness in the left lower quadrant of the abdomen, nausea, vomiting, constipation or diarrhea, fever and leukocytosis .
Acute diverticulitis is thought to arise from either trauma or lack of blood flow to the existing diverticulum in the colon. The traumatic theory proposes that a fecalith, which is a hardened fecal matter, becomes trapped in a diverticulum, leading to colonic mucosa abrasion and local inflammation.
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A hyclate (Latin: hyclas) is a pharmaceutical term for hydrochloride hemiethanolate hemihydrate [1] [2] (·HCl· 1 / 2 EtOH· 1 / 2 H 2 O), e.g. doxycycline hyclate. [ 3 ] [ 4 ] References
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