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  2. Rivaroxaban - Wikipedia

    en.wikipedia.org/wiki/Rivaroxaban

    Rivaroxaban, sold under the brand name Xarelto among others, is an anticoagulant medication (blood thinner) used to treat and prevent blood clots. [8] Specifically it is used to treat deep vein thrombosis and pulmonary emboli and prevent blood clots in atrial fibrillation and following hip or knee surgery. [ 8 ]

  3. Discovery and development of direct Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    Rivaroxaban. During the SAR development of rivaroxaban, researchers realized that adding a 5-chlorothiophene-2-carboxamide group to the oxazolidonine core could increase the potency by 200 fold, which had previously been too weak for medical use. In addition to this discovery, a clear preference for the (S)-configuration was confirmed.

  4. Direct factor Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Direct_factor_Xa_inhibitors

    Antistasin, the first discovered naturally occurring direct Xa inhibitor Rivaroxaban, the first synthetic direct Xa inhibitor marketed as a drug Prior to the introduction of direct factor Xa inhibitors, vitamin K antagonists such as warfarin were the only oral anticoagulants for over 60 years, and together with heparin have been the main blood ...

  5. Bayer's patent for blood thinner Xarelto invalid, UK court rules

    www.aol.com/news/bayers-patent-blood-thinner...

    Bayer's patent covering its best-selling blood thinner Xarelto is invalid, London's High Court ruled on Friday in a blow to the German drugmaker. The company's blockbuster Xarelto drug generated ...

  6. Doctors Say This Viral "Sleep Rule" Actually Works - AOL

    www.aol.com/doctors-viral-sleep-rule-actually...

    It's a series of pre-bedtime steps you take throughout the day to prepare you for a better night of sleep. And doctors say these guidelines could actually help you focus on adopting healthier ...

  7. Experts Reveal the Exact Time to Shower for Better Sleep - AOL

    www.aol.com/lifestyle/experts-reveal-exact-time...

    A good night’s rest all starts when you say “rise and shine” that a.m. To improve your sleep at night, establish a consistent morning routine: Focus on waking up around the same time each ...

  8. every morning: quaque ante meridiem q.d., qd every day / daily quaque die q.h.s., qhs every night at bedtime quaque hora somni q.d.s, qds, QDS 4 times a day quater die sumendum q.i.d, qid 4 times a day quater in die q.h., qh every hour, hourly quaque hora q.o.d., qod every other day / alternate days quaque altera die q.p.m., qPM, qpm

  9. The Best Time to Eat Breakfast If You Have High Cholesterol ...

    www.aol.com/best-time-eat-breakfast-high...

    For extra cholesterol-lowering power, Rouse suggests reaching for more plant-based foods in the morning. Fruits, vegetables, nuts, seeds and whole grains provide nutrients like soluble fiber ...