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Elevated alkaline phosphatase occurs when levels of alkaline phosphatase (ALP) exceed the reference range. This group of enzymes has a low substrate specificity and catalyzes the hydrolysis of phosphate esters in a basic environment. The major function of alkaline phosphatase is transporting chemicals across cell membranes. [1]
Glucocorticoids lower the serum concentration of thyroxine and triiodothyronine. 40-50% of dogs with Cushing's have lowered levels of these thyroid hormones. The cause of this is not known. When a dog has lowered serum levels of thyroid hormones and endocrine alopecia it is harder to differentiate between hypothyroidism and Cushing's.
Alkaline phosphatase levels are usually high in hyperparathyroidism due to high bone turn over. In primary hyperparathyroidism, levels may remain within the normal range, but this is inappropriately normal given the increased levels of plasma calcium. [citation needed]
The enzyme alkaline phosphatase (ALP, alkaline phenyl phosphatase) is a phosphatase with the physiological role of dephosphorylating compounds. The enzyme is found across a multitude of organisms, prokaryotes and eukaryotes alike, with the same general function, but in different structural forms suitable to the environment they function in. Alkaline phosphatase is found in the periplasmic ...
Laboratory findings include low-normal serum calcium, moderately low serum phosphate, elevated serum alkaline phosphatase, and low serum 1,25 dihydroxy-vitamin D levels, hyperphosphaturia, and no evidence of hyperparathyroidism. [8] Hypophosphatemia decreases 2,3-bisphosphoglycerate (2,3-BPG) causing a left shift in the oxyhemoglobin curve.
The omnivorous domestic dog was originally primarily carnivore but has evolved to metabolize carbohydrates, fat, and fiber and remain healthy on a diet lower in protein. A systematic review of studies from 2023 found no evidence of detrimental effects of vegetarian diets for dogs; however, the authors pointed out studies tended to have a small ...
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