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  2. Hox gene - Wikipedia

    en.wikipedia.org/wiki/Hox_gene

    The same Hox protein can act as a repressor at one gene and an activator at another. The ability of Hox proteins to bind DNA is conferred by a part of the protein referred to as the homeodomain. The homeodomain is a 60-amino-acid-long DNA-binding domain (encoded by its corresponding 180-base-pair DNA sequence, the homeobox

  3. Homeobox - Wikipedia

    en.wikipedia.org/wiki/Homeobox

    Homeobox genes encode homeodomain protein products that are transcription factors sharing a characteristic protein fold structure that binds DNA to regulate expression of target genes. [ 3 ] [ 4 ] [ 2 ] Homeodomain proteins regulate gene expression and cell differentiation during early embryonic development, thus mutations in homeobox genes can ...

  4. HOXB13 - Wikipedia

    en.wikipedia.org/wiki/HOXB13

    10481 15408 Ensembl ENSG00000159184 ENSMUSG00000049604 UniProt Q92826 P70321 RefSeq (mRNA) NM_006361 NM_008267 RefSeq (protein) NP_006352 NP_032293 Location (UCSC) Chr 17: 48.72 – 48.73 Mb n/a PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Hox-B13 is a protein that in humans is encoded by the HOXB13 gene. Function This gene encodes a transcription factor that belongs ...

  5. HOXC6 - Wikipedia

    en.wikipedia.org/wiki/HOXC6

    Homeobox protein Hox-C6 is a protein that in humans is encoded by the HOXC6 gene. [5] [6] [7] Hox-C6 expression is highest in the fallopian tube and ovary. [8]HoxC6 has been highly expressed in many types of cancers including prostate, breast, and esophageal squamous cell cancer.

  6. PITX2 - Wikipedia

    en.wikipedia.org/wiki/PITX2

    Paired-like homeodomain transcription factor 2 also ... [19] ovarian, [20] and colon cancer ... In Congenital Heart Disease, heterozygous mutations in Pitx2 have ...

  7. PHOX2B - Wikipedia

    en.wikipedia.org/wiki/PHOX2B

    Mutations in human PHOX2B cause a rare disease of the visceral nervous system (dysautonomia): congenital central hypoventilation syndrome (associated with respiratory arrests during sleep and, occasionally, wakefulness), Hirschsprung's disease (partial agenesis of the enteric nervous system), ROHHAD, and tumours of the sympathetic ganglia.

  8. HOXD10 - Wikipedia

    en.wikipedia.org/wiki/HOXD10

    15430 Ensembl ENSG00000128710 ENSMUSG00000050368 UniProt P28358 P28359 RefSeq (mRNA) NM_002148 NM_013554 RefSeq (protein) NP_002139 NP_038582 Location (UCSC) Chr 2: 176.11 – 176.12 Mb Chr 2: 74.52 – 74.53 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox D10, also known as HOXD10, is a protein which in humans is encoded by the HOXD10 gene. Function This gene is a member of ...

  9. Homeotic selector gene - Wikipedia

    en.wikipedia.org/wiki/Homeotic_selector_gene

    Homeodomain proteins are transcription factors that share a DNA-binding domain called the homeodomain. [1] Changes in the expression and function of homeotic genes are responsible for the changes in the morphology of the limbs of arthropods as well as in the axial skeletons of vertebrates.