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Homeobox genes encode homeodomain protein products that are transcription factors sharing a characteristic protein fold structure that binds DNA to regulate expression of target genes. [ 3 ] [ 4 ] [ 2 ] Homeodomain proteins regulate gene expression and cell differentiation during early embryonic development, thus mutations in homeobox genes can ...
Men who inherit a rare (<0.1% in a selected group of patients without clinical signs of prostate cancer) genetic variant in HOXB13 (G84E or rs138213197) have a 10-20-fold increased risk of prostate cancer. [7] [8]
The same Hox protein can act as a repressor at one gene and an activator at another. The ability of Hox proteins to bind DNA is conferred by a part of the protein referred to as the homeodomain. The homeodomain is a 60-amino-acid-long DNA-binding domain (encoded by its corresponding 180-base-pair DNA sequence, the homeobox
15405 Ensembl ENSG00000078399 ENSMUSG00000038227 UniProt P31269 P09631 RefSeq (mRNA) NM_152739 NM_002142 NM_001277238 NM_010456 RefSeq (protein) NP_689952 NP_001264167 NP_034586 Location (UCSC) Chr 7: 27.16 – 27.18 Mb Chr 6: 52.2 – 52.21 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Hox-A9 is a protein that in humans is encoded by the HOXA9 gene. In vertebrates ...
Homeodomain proteins are transcription factors that share a DNA-binding domain called the homeodomain. [1] Changes in the expression and function of homeotic genes are responsible for the changes in the morphology of the limbs of arthropods as well as in the axial skeletons of vertebrates.
15394 Ensembl ENSG00000105991 ENSMUSG00000029844 UniProt P49639 P09022 RefSeq (mRNA) NM_153620 NM_005522 NM_010449 NM_001311118 RefSeq (protein) NP_005513 NP_705873 n/a Location (UCSC) Chr 7: 27.09 – 27.1 Mb Chr 6: 52.13 – 52.14 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein Hox-A1 is a protein that in humans is encoded by the HOXA1 gene. Gene Two transcript ...
NANOG is highly expressed in cancer stem cells and may thus function as an oncogene to promote carcinogenesis. High expression of NANOG correlates with poor survival in cancer patients. [20] [21] [22] Recent research has shown that the localization of NANOG and other transcription factors have potential consequences on cellular function.
HNF1A mutations can cause maturity onset diabetes of the young type 3, one of the forms of "monogenic diabetes", [6] as well as hepatocellular adenoma. HNF-1 protein is present in ovarian clear-cell carcinoma. [29] [30] In humans, mutations in HNF1A cause diabetes that responds to low dose sulfonylurea agents. [31]