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Inhibition of IκB kinase (IKK) and IKK-related kinases, IKBKE (IKKε) and TANK-binding kinase 1 (TBK1), has been investigated as a therapeutic option for the treatment of inflammatory diseases and cancer. [11] The small-molecule inhibitor of IKK-β SAR113945, developed by Sanofi-Aventis, was evaluated in patients with knee osteoarthritis. [11 ...
IKK-β is an enzyme that serves as a protein subunit of IκB kinase, which is a component of the cytokine-activated intracellular signaling pathway involved in triggering immune responses. IKK's activity causes activation of a transcription factor known as Nuclear Transcription factor kappa-B or NF-κB.
Activation of the NF-κB is initiated by the signal-induced degradation of IκB proteins. This occurs primarily via activation of a kinase called the IκB kinase (IKK). IKK is composed of a heterodimer of the catalytic IKKα and IKKβ subunits and a "master" regulatory protein termed NEMO (NF-κB essential modulator) or IKKγ. When activated by ...
Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD (TANK-binding kinase 1-binding protein 1) can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD .
18035 Ensembl ENSG00000100906 ENSMUSG00000021025 UniProt P25963 Q9Z1E3 RefSeq (mRNA) NM_020529 NM_010907 RefSeq (protein) NP_065390 NP_035037 Location (UCSC) Chr 14: 35.4 – 35.4 Mb Chr 12: 55.54 – 55.54 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse IκBα (n uclear f actor of k appa light polypeptide gene enhancer in B -cells i nhibitor a lpha; NFKBIA) is one member of a family ...
Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-α) also known as IKK1 or conserved helix-loop-helix ubiquitous kinase (CHUK) is a protein kinase that in humans is encoded by the CHUK gene. [5] IKK-α is part of the IκB kinase complex that plays an important role in regulating the NF-κB transcription factor. [6]
NF-kappa-B essential modulator (NEMO) also known as inhibitor of nuclear factor kappa-B kinase subunit gamma (IKK-γ) is a protein that in humans is encoded by the IKBKG gene. NEMO is a subunit of the IκB kinase complex that activates NF-κB. [5] The human gene for IKBKG is located on the chromosome band Xq28. [6]
Familial dysautonomia is the result of mutations in the IKBKAP gene on chromosome 9, which encodes for the IKAP protein (IkB kinase complex-associated protein). Three mutations in IKBKAP have been identified in individuals with FD. The most common FD-causing mutation occurs in intron 20 of the donor gene.