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The first avian picornavirus to have its genome sequenced, [3] it causes epidemic tremor in chickens. Tremovirus is of economic importance to chicken farmers because it causes a drop in egg production in laying hens, and neurological diseases in chicks less than three weeks old.
Management of ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome) focuses on symptoms management, as no treatments that address the root cause of the illness are available. [ 1 ] : 29 Pacing, or regulating one's activities to avoid triggering worse symptoms, is the most common management strategy for post-exertional malaise .
Rintatolimod, sold under the tradename Ampligen, is a medication intended for treatment of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). [1] There is some evidence it may improve some ME/CFS symptoms. [1] It is an immunomodulatory double-stranded RNA drug similar to the prototypical RNA poly I:C.
It can be further categorized in three subtypes: antibody-negative probable autoimmune encephalitis, autoimmune limbic encephalitis and acute disseminated encephalomyelitis. [4] One therapeutic approach to seronegative autoimmune encephalitis is using as a first-line treatment corticosteroids and intravenous immunoglobulin. [4]
Treatment is usually supportive in nature while also providing antiviral drug therapy. The primary exception to this is herpes simplex encephalitis, which is treatable with acyclovir . Prognosis is good for most individuals who are infected by an encephalitic virus but is poor among those who develop severe symptoms, including viral encephalitis.
Encephalomyelitis is inflammation of the brain and spinal cord. Various types of encephalomyelitis include: Acute disseminated encephalomyelitis or postinfectious encephalomyelitis, a demyelinating disease of the brain and spinal cord, possibly triggered by viral infection. [1] [2] Encephalomyelitis disseminata, a synonym for multiple sclerosis.
Despite ample evidence that ME/CFS is an organic disease, many clinicians do not recognise it as genuine or underestimate its seriousness. [6] [1] [4] A 2020 literature review found that “a third to a half of all GPs did not accept ME/CFS as a genuine clinical entity and, even when they did, they lacked confidence in diagnosing or managing it.” [4]
Nearly all people with paraneoplastic sensory neuronopathy and encephalomyelitis associated with small-cell lung cancer have anti-Hu antibodies in their serum, and the condition has been found to occur with other tumor types expressing Hu antigen. [10]