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In a phase 1-2 open-label study treatment with CM313, a novel anti-CD38 monoclonal antibody, rapidly boosted platelet levels in adults with ITP by inhibiting antibody-dependent cell-mediated cytotoxicity on platelets; maintained long-term efficacy by clearing plasma cells; and was associated with low-grade toxic effects.
Thrombotic thrombocytopenic purpura (TTP) is a blood disorder that results in blood clots forming in small blood vessels throughout the body. [2] This results in a low platelet count, low red blood cells due to their breakdown, and often kidney, heart, and brain dysfunction. [1]
Congenital amegakaryocytic thrombocytopenia is most likely caused by a mutation in the gene for the TPO receptor, c-mpl, despite high levels of serum TPO. [2] [6] In addition, there may be abnormalities with the central nervous system including the cerebrum and cerebellum which could cause symptoms. [2]
The UpToDate system is an evidence-based clinical resource. It includes a collection of medical and patient information, access to Lexicomp drug monographs and drug-to-drug interactions, and a number of medical calculators. UpToDate is written by over 7,100 physician authors, editors, and peer reviewers. It is available both via the Internet ...
The timing, severity of the thrombocytopenia, the occurrence of new thrombosis, and the presence of alternative explanations, all determine the likelihood that HIT is present. A commonly used score to predict the likelihood of HIT is the "4 Ts" score introduced in 2003. [10] A score of 0–8 points is generated; if the score is 0–3, HIT is ...
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We love a roasted vegetable—whether it's a creamy-crisp potato or onion-smothered cauliflower—and we appreciate the convenience of frozen veggies. But it wasn't until recently that we embraced ...
[1] [2] These immune cytopenias may occur simultaneously or sequentially. [1] [3] Its overall phenotype resembles a combination of autoimmune hemolytic anemia and immune thrombocytopenic purpura. [1] [4] [5] Autoimmune hemolytic anemia is a condition in which the red blood cells that normally carry oxygen are destroyed by an autoimmune process ...
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