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Nephrotoxicity is toxicity in the kidneys. It is a poisonous effect of some substances, both toxic chemicals and medications, on kidney function. [1] There are various forms, [2] and some drugs may affect kidney function in more than one way. Nephrotoxins are substances displaying nephrotoxicity.
Potential side effects include angioedema, nephrotoxicity, and low blood pressure. [10] It was approved for medical use in the United States and in the European Union in 2015, [11] [12] [13] [7] and in Australia in 2016. [1] In 2022, it was the 165th most commonly prescribed medication in the United States, with more than 3 million prescriptions.
The medication or drug is commonly used to treat alcohol use disorder, and results in immediate hangover-like symptoms upon consumption of alcohol, this effect is widely known as disulfiram effect. Metronidazole
“It’s a growing problem. Alcohol is a very simple molecule with very diverse effects on physiology,” explains White. “There aren’t many things the body does that alcohol doesn’t impact.”
This prescription medication, known as naltrexone, is used to treat alcohol use disorder and opioid use disorder by reducing cravings and feelings of euphoria associated with the use of alcohol or ...
A 2020 systematic review and meta-analysis concluded that there is no definitive link between alcohol-based mouthwash use and the risk of oral cancer. [21] This should not be confused with the fact that alcohol consumption at any quantity is a risk factor for alcohol and cancer such as cancers of the mouth, esophagus, pharynx and larynx. [22]
The drug itself is also known to be nephrotoxic, opening up the possibility of spontaneous emergence of toxicity at doses that were previously well-tolerated. Lithium toxicity can be mistaken for other syndromes associated with antipsychotic use, such as serotonin syndrome because lithium increases serotonin metabolites in the cerebrospinal fluid .
Finally, note that the benzodiazepine core is a privileged scaffold, which has been used to derive drugs with diverse activity that is not limited to the GABA A modulatory action of the classical benzodiazepines, [60] such as devazepide and tifluadom, however these have not been included in the list below. 2,3-benzodiazepines such as tofisopam ...