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A carcinogen (/ k ɑːr ˈ s ɪ n ə dʒ ən /) is any agent that promotes the development of cancer. [1] Carcinogens can include synthetic chemicals , naturally occurring substances, physical agents such as ionizing and non-ionizing radiation , and biologic agents such as viruses and bacteria . [ 2 ]
IARC group 1 Carcinogens are substances, chemical mixtures, and exposure circumstances which have been classified as carcinogenic to humans by the International Agency for Research on Cancer (IARC). [1] This category is used when there is sufficient evidence of carcinogenicity in humans.
IARC group 2B substances, mixtures and exposure circumstances are those that have been classified as "possibly carcinogenic to humans" by the International Agency for Research on Cancer (IARC) as [1] This category is used when there is limited evidence of carcinogenicity in humans and less than sufficient evidence of carcinogenicity in experimental animals.
The central role of DNA damage and epigenetic defects in DNA repair genes in carcinogenesis. DNA damage is considered to be the primary cause of cancer. [17] More than 60,000 new naturally-occurring instances of DNA damage arise, on average, per human cell, per day, due to endogenous cellular processes (see article DNA damage (naturally occurring)).
Chemotherapy drugs such as platinum-based compounds are carcinogens that increase the risk of secondary cancers [46] Azathioprine, an immunosuppressive medication, is a carcinogen that can cause primary tumors to develop. [46]
The analysis, published in the journal Frontiers in Toxicology, builds upon research published earlier this year, which identified more than 900 chemicals as being potential mammory carcinogens ...
The World Health Organization has identified glyphosate as "possibly carcinogenic to humans" and a study published earlier this year showed that glyphosate raised the cancer risk of those exposed ...
IARC group 2A agents are substances and exposure circumstances that have been classified as probable carcinogens by the International Agency for Research on Cancer (IARC). [1] This designation is applied when there is limited evidence of carcinogenicity in humans, as well as sufficient evidence of carcinogenicity in experimental animals.