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Wolfram syndrome, also called DIDMOAD (diabetes insipidus, diabetes mellitus, optic atrophy, and deafness), is a rare autosomal-recessive genetic disorder that causes childhood-onset diabetes mellitus, optic atrophy, and deafness as well as various other possible disorders including neurodegeneration.
A fasting blood sugar level of ≥ 7.0 mmol / L (126 mg/dL) is used in the general diagnosis of diabetes. [17] There are no clear guidelines for the diagnosis of LADA, but the criteria often used are that the patient should develop the disease in adulthood, not need insulin treatment for the first 6 months after diagnosis and have autoantibodies in the blood.
Diabetes, for example, is the leading cause of new cases of blindness in those aged 20–74, with ocular manifestations such as diabetic retinopathy and macular edema affecting up to 80% of those who have had the disease for 15 years or more.
o symptoms Zero symptoms ϕ Horizontal orthophoria θ Vertical orthophoria ⊕ Horizontal and vertical orthophoria OC's Optical centres Occ. Occupation OD oculus dexter (right eye) OH Ocular history OMB Oculo motor balance ONH Optic nerve head Oph Ophthalmoscopy OS oculus sinister (left eye) OU oculus uterque (both eyes) PD Pupillary distance
The causes of macular edema are numerous and different causes may be inter-related. It is commonly associated with diabetes.Chronic or uncontrolled diabetes type 2 can affect peripheral blood vessels including those of the retina which may leak fluid, blood and occasionally fats into the retina causing it to swell.
Symptoms include “sensitivity to light, dizziness, pain behind the eyes, nausea, vomiting, and rash,” the CDC says, while more serious disease includes meningitis, encephalitis, and bleeding.
It is categorized as "macular perifoveal telangiectasia", a neurodegenerative metabolic disorder, correlated with diabetes and coronary artery disease. It generally affects both eyes and usually affects both sexes equally. Type 3 is an extremely rare, poorly understood neurological disease of the retina.
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