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A serotonin pathway identifies aggregate projections from neurons which synthesize and communicate the monoamine neurotransmitter serotonin. [citation needed] These pathways are relevant to different psychiatric and neurological disorders. [1] [2] [3]
The 5-HT 3 receptor is expressed throughout the central and peripheral nervous systems and mediates a variety of physiological functions. [14] On a cellular level, it has been shown that postsynaptic 5-HT 3 receptors mediate fast excitatory synaptic transmission in rat neocortical interneurons, amygdala , and hippocampus, and in ferret visual ...
The MRN is involved in the serotonin pathway. [3] Serotonin (5-HT) is the chief neurotransmitter of the median raphe nucleus. [4] According to one study, it represents the main source of serotonin (5-hydroxytryptamine (5-HT)) in the brain. [3] Stimulation of the MRN significantly increases the amount of 5-HT present in the brain. [5]
The serotonin created by the brain comprises around 10% of total body serotonin. The majority (80-90%) is found in the gastrointestinal (GI) tract. [15] [16] It travels around the brain along the medial forebrain bundle and acts on serotonin receptors. In the peripheral nervous system (such as in the gut wall) serotonin regulates vascular tone.
5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. [ 1 ] [ 2 ] [ 3 ] They mediate both excitatory and inhibitory neurotransmission .
Serotonin (/ ˌ s ɛr ə ˈ t oʊ n ɪ n, ˌ s ɪər ə-/) [6] [7] [8] or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.Its biological function is complex, touching on diverse functions including mood, cognition, reward, learning, memory, and numerous physiological processes such as vomiting and vasoconstriction.
A study by Brown, Edwards, McKone and Ward (2007), [3] additionally investigated MDMA's effect on serotonin neurons. Their research also stemmed from Masini et al. (1990). [18] They were interested in serotonin's role in lateral inhibition to orientation sensitive neurons and how MDMA use may change this system and produce wider tuning ...
The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene. [5] SERT is a type of monoamine transporter protein that transports the neurotransmitter serotonin from the synaptic cleft back to the presynaptic ...