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Transition metal alkyne complexes are often formed by the displacement of labile ligands by the alkyne. For example, a variety of cobalt-alkyne complexes arise by the reaction of alkynes with dicobalt octacarbonyl. [2] Co 2 (CO) 8 + R 2 C 2 → (R 2 C 2)Co 2 (CO) 6 + 2 CO. Many alkyne complexes are produced by reduction of metal halides: [3]
An important driving force for this type of reaction is the expulsion of small gaseous molecules such as acetylene or but-2-yne. The same two-step procedure was used in the synthesis of the naturally occurring cyclophane turriane. Trisamidomolybdenum(VI) alkylidyne complexes catalyze alkyne metathesis. [12]
The Seyferth–Gilbert homologation is a chemical reaction of an aryl ketone 1 (or aldehyde) with dimethyl (diazomethyl)phosphonate 2 and potassium tert-butoxide to give substituted alkynes 3. [1] [2] Dimethyl (diazomethyl)phosphonate 2 is often called the Seyferth–Gilbert reagent. [3] The Seyferth–Gilbert homologation
The alkyne zipper reaction is an organic reaction that involves isomerization of a non terminal alkyne into a terminal alkyne. This reaction was first reported by Alexey Favorsky in 1887 (J. Russ. Phys.-Chem. Soc., 19, 414 (1887)). Also, this reaction was reported by Charles Allen Brown and Ayako Yamashita in 1975. [1] The isomerization ...
An alkyne trimerisation is a [2+2+2] cycloaddition reaction in which three alkyne units (C≡C) react to form a benzene ring. The reaction requires a metal catalyst. The process is of historic interest as well as being applicable to organic synthesis. [1] Being a cycloaddition reaction, it has high atom economy.
The Larock indole synthesis is a flexible reaction partly due to the variety of substituted alkynes that can be used in the annulation reaction. In particular, alkynes with substituents including alkyls, aryls, alkenyls, hydroxyls, and silyls have been successfully used. [3] However, bulkier tertiary alkyl or trimethylsilyl groups have been ...
The reaction can be carried out under mild conditions, such as at room temperature, in aqueous media, and with a mild base, which has allowed for the use of the Sonogashira cross-coupling reaction in the synthesis of complex molecules. Its applications include pharmaceuticals, natural products, organic materials, and nanomaterials. [1]
The Pauson–Khand (PK) reaction is a chemical reaction, described as a cycloaddition.In it, an alkyne, an alkene, and carbon monoxide combine into a α,β-cyclopentenone in the presence of a metal-carbonyl catalyst [1] [2] Ihsan Ullah Khand (1935–1980) discovered the reaction around 1970, while working as a postdoctoral associate with Peter Ludwig Pauson (1925–2013) at the University of ...