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The cell cycle inhibitor p27kip1 has also been found to encourage regrowth of cochlear hair cells in mice following genetic deletion or knock down with siRNA targeting p27. [36] [37] Research on hair cell regeneration may bring us closer to clinical treatment for human hearing loss caused by hair cell damage or death.
There are two types of hair cells specific to the auditory system; inner and outer hair cells. Inner hair cells are the mechanoreceptors for hearing: they transduce the vibration of sound into electrical activity in nerve fibers, which is transmitted to the brain. Outer hair cells are a motor structure.
The Human Brain Project is a large scientific research project, starting in 2013, which aims to simulate the complete human brain. The field of neuroscience encompasses all approaches that seek to understand the brain and the rest of the nervous system. [ 8 ]
The adult human brain is estimated to contain 86±8 billion neurons, with a roughly equal number (85±10 billion) of non-neuronal cells. [41] Out of these neurons, 16 billion (19%) are located in the cerebral cortex, and 69 billion (80%) are in the cerebellum.
A sensory system consists of sensory neurons (including the sensory receptor cells), neural pathways, and parts of the brain involved in sensory perception and interoception. Commonly recognized sensory systems are those for vision, hearing, touch, taste, smell, balance and visceral sensation.
The Outer ear consists of the pinna or auricle (visible parts including ear lobes and concha), and the auditory meatus (the passageway for sound). The fundamental function of this part of the ear is to gather sound energy and deliver it to the eardrum. Resonances of the external ear selectively boost sound pressure with frequency in the range 2 ...
This causes the cell to depolarise, and creates an action potential that is transmitted along the spiral ganglion, which sends information through the auditory portion of the vestibulocochlear nerve to the temporal lobe of the brain. [13] The human ear can generally hear sounds with frequencies between 20 Hz and 20 kHz (the audio range).
3D model of cochlea and semicircular canals. The cochlea is the part of the inner ear involved in hearing.It is a spiral-shaped cavity in the bony labyrinth, in humans making 2.75 turns around its axis, the modiolus.