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The endothelium is a thin layer of single flat cells that line the interior surface of blood vessels and lymphatic vessels. [1] Endothelium is of mesodermal origin. Both blood and lymphatic capillaries are composed of a single layer of endothelial cells called a monolayer. In straight sections of a blood vessel, vascular endothelial cells ...
Atherosclerosis, the narrowing of the blood vessels due to the buildup of plaque, and the coronary artery disease that often follows can cause heart attacks or cardiac arrest and is the leading cause of death worldwide resulting in 8.9 million deaths or 16% of all deaths. [17] [18] Blood vessel permeability is increased in inflammation.
The tunica intima (Neo-Latin "inner coat"), or intima for short, is the innermost tunica (layer) of an artery or vein. It is made up of one layer of endothelial cells (and macrophages in areas of disturbed blood flow), [1][2] and is supported by an internal elastic lamina. The endothelial cells are in direct contact with the blood flow.
The layers known as tunicae have a concentric arrangement that forms the wall of the vessel. The outer layer, is a thick layer of connective tissue called the tunica externa or adventitia; this layer is absent in the post-capillary venules. [4] The middle layer, consists of bands of smooth muscle and is known as the tunica media.
A capillary is a small blood vessel, from 5 to 10 micrometres in diameter, and is part of the microcirculation system. Capillaries are microvessels and the smallest blood vessels in the body. They are composed of only the tunica intima (the innermost layer of an artery or vein), consisting of a thin wall of simple squamous endothelial cells. [2]
Tunica media. Transverse section through a small artery and vein of the mucous membrane of the epiglottis of a child. (Tunica media is at 'm'.) The tunica media (Neo-Latin "middle coat"), or media for short, is the middle tunica (layer) of an artery or vein. [1] It lies between the tunica intima on the inside and the tunica externa on the outside.
Tunica externa. Section of a medium-sized artery. The tunica externa (Neo-Latin "outer coat"), also known as the tunica adventitia (Neo-Latin "additional coat"), [1][2] is the outermost tunica (layer) of a blood vessel, surrounding the tunica media. It is mainly composed of collagen and, in arteries, is supported by external elastic lamina.
Microcirculation. The microcirculation is the circulation of the blood in the smallest blood vessels, the microvessels of the microvasculature present within organ tissues. [ 1 ] The microvessels include terminal arterioles, metarterioles, capillaries, and venules. Arterioles carry oxygenated blood to the capillaries, and blood flows out of the ...