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Retinoic acid (simplified nomenclature for all-trans-retinoic acid) is a metabolite of vitamin A 1 (all-trans-retinol) that is required for embryonic development, male fertility, regulation of bone growth and immune function. [2] All-trans-retinoic acid is required for chordate animal development, which includes all higher animals from fish to ...
For all-trans-retinoic acid as the metabolite of vitamin A, see Retinoic acid. Tretinoin, also known as all-trans retinoic acid (ATRA), is a medication used for the treatment of acne and acute promyelocytic leukemia. [ 8 ][ 9 ][ 10 ] For acne, it is applied to the skin as a cream, gel or ointment. [ 10 ]
Retinol, also called vitamin A1, is a fat-soluble vitamin in the vitamin A family that is found in food and used as a dietary supplement. [ 3 ] Retinol or other forms of vitamin A are needed for vision, cellular development, maintenance of skin and mucous membranes, immune function and reproductive development. [ 3 ]
First generation retinoids are produced naturally in the body and interact with their normal biological counterparts, such as retinol binding protein 4 for retinol, retinoid receptors for all-trans-retinoic acid or 9-cis-retinoic acid. [7] 13-cis retinoic acid has an unknown biological pathway but appears to act as a growth factor. [8]
As for the risks of too much RA during embryogenesis, the prescription drugs tretinoin (all-trans-retinoic acid) and isotretinoin (13-cis-retinoic acid), used orally or topically for acne treatment, are labeled with block-box warnings for pregnant women or women who may become pregnant, as they are known human teratogens. [31] [32]
Retinyl palmitate is used as a source of vitamin A added to low fat milk and other dairy products to replace the vitamin content lost through the removal of milk fat. Palmitate is attached to the alcohol form of vitamin A, retinol, in order to make vitamin A stable in milk. [citation needed] Retinyl palmitate is also a constituent of some ...
Isotretinoin, also known as 13-cis-retinoic acidand sold under the brand name Accutaneamong others, is a medication used to treat skin diseases like harlequin-type ichthyosis, and lamellar ichthyosis, and severe cystic acneor moderate acne that is unresponsive to antibiotics.[6] Isotretinoin is used off-label to treat basal cell carcinomaand ...
Retinyl acetate (retinol acetate, vitamin A acetate) is a natural [dubious– discuss ] form of vitamin A which is the acetate ester of retinol. It has potential antineoplastic and chemopreventive activities. [ 2 ][ 3 ] In the United States, retinyl acetate is classified generally recognized as safe (GRAS) in the amounts used to fortify foods ...